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Article

Ribosomal RNA and protein mutants resistant to spectinomycin.

The EMBO journal - 1 Mar 1990

Bilgin N, Richter A A, Ehrenberg M, Dahlberg A E, Kurland C G

Abstract excerpt

We have compared the influence of spectinomycin (Spc) on individual partial reactions during the elongation phase of translation in vitro by wild-type and mutant ribosomes. The data show that the antibiotic specifically inhibits the elongation factor G (EF-G) cycle supported by wild-type ribosomes. In addition, we have reproduced the in vivo Spc resistant phenotype of relevant ribosome mutants in our in vitro...

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Identifiers

PMID: 2138078
DOI: 10.1002/j.1460-2075.1990.tb08167.x
PMCID: PMC551729

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Source receipt: pubmed, retrieved 7 Sept 2026.

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