Article
Efflux-mediated aminoglycoside and macrolide resistance in Burkholderia pseudomallei.
Antimicrobial agents and chemotherapy - 1 Mar 1999
Moore R A, DeShazer D, Reckseidler S, Weissman A, Woods D E
Abstract excerpt
Burkholderia pseudomallei, the causative agent of melioidosis, is intrinsically resistant to a wide range of antimicrobial agents including beta-lactams, aminoglycosides, macrolides, and polymyxins. We used Tn5-OT182 to mutagenize B. pseudomallei to identify the genes involved in aminoglycoside resistance. We report here on the identification of AmrAB-OprA, a multidrug efflux system in B. pseudomallei which is...
Topics
- Animals
- Anti-Bacterial Agents
- Burkholderia pseudomallei
- Colony Count, Microbial
- Cricetinae
- DNA Transposable Elements
- Drug Resistance, Microbial
- Drug Resistance, Multiple
- Genetic Complementation Test
- Lac Operon