Article
Mechanisms of streptomycin resistance: selection of mutations in the 16S rRNA gene conferring resistance.
Antimicrobial agents and chemotherapy - 1 Oct 2001
Springer B, Kidan Y G, Prammananan T, Ellrott K, Böttger E C, Sander P
Abstract excerpt
Chromosomally acquired streptomycin resistance is frequently due to mutations in the gene encoding the ribosomal protein S12, rpsL. The presence of several rRNA operons (rrn) and a single rpsL gene in most bacterial genomes prohibits the isolation of streptomycin-resistant mutants in which resistance is mediated by mutations in the 16S rRNA gene (rrs). Three strains were constructed in this investigation:...
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