The contribution of a novel ribosomal S12 mutation to aminoglycoside resistance of Escherichia coli mutants.

doi:10.1179/joc.2004.16.4.347

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Article

The contribution of a novel ribosomal S12 mutation to aminoglycoside resistance of Escherichia coli mutants.

Journal of chemotherapy (Florence, Italy) - 1 Aug 2004

Gill A E, Amyes S G B

Abstract excerpt

This study characterised the contribution of a novel ribosomal S12 mutation to aminoglycoside resistance in Escherichia coli via step-wise mutation analysis. Mutants of E. coli NCTC 10418 were selected in four separate progressive series (I-IV) on plates containing increasing aminoglycoside (streptomycin, neomycin, gentamicin, tobramycin, and kanamycin) concentrations. Minimum inhibitory concentrations (MICs) of...

Topics

Aminoglycosides
Cross Reactions
Drug Resistance, Bacterial
Escherichia coli
Escherichia coli Infections
Escherichia coli Proteins
Humans
Microbial Sensitivity Tests
Mutation
Pharmacogenetics
Polymerase Chain Reaction
Ribosomal Protein S9
Ribosomal Proteins
Sampling Studies
Sensitivity and Specificity

Source

Open in PubMed

Identifiers

PMID: 15332709
DOI: 10.1179/joc.2004.16.4.347

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