Article

How medically important antimicrobials bind to the 30S ribosomal subunit in a bacterial pathogen

2025-12-25

Abstract excerpt

Ribosomes translate the genetic code in mRNA to synthesize proteins in all living organisms. Decoding of mRNA occurs in the small subunit of the ribosome and is mediated by tRNA anticodons. Regions near the decoding center are a target for antibiotics, such as aminoglycosides and tetracyclines, where their presence results in errors in protein synthesis. More than two decades of high-resolution structural studies...

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Literature Corpus work: 1ad4d270-43f5-552c-be16-295b99dc133a
DOI: 10.64898/2025.12.24.696192

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