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Article

Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2016

Cocozaki Alexis I, Altman Roger B, Huang Jian, Buurman Ed T, Kazmirski Steven L, Doig Peter, Prince D Bryan, Blanchard Scott C, Cate Jamie H D, Ferguson Andrew D

Abstract excerpt

Mutations conferring resistance to translation inhibitors often alter the structure of rRNA. Reduced susceptibility to distinct structural antibiotic classes may, therefore, emerge when a common ribosomal binding site is perturbed, which significantly reduces the clinical utility of these agents. The translation inhibitors negamycin and tetracycline interfere with tRNA binding to the aminoacyl-tRNA site on the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 27382179
DOI: 10.1073/pnas.1605127113
PMCID: PMC4961145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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