Association analysis of TPH-1 and TPH-2 genes with suicidal behavior in patients with attempted suicide in Mexican population.

doi:10.1016/j.comppsych.2015.05.002

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Article

Association analysis of TPH-1 and TPH-2 genes with suicidal behavior in patients with attempted suicide in Mexican population.

Comprehensive psychiatry - 1 Aug 2015

López-Narváez María Lilia, Tovilla-Zárate Carlos Alfonso, González-Castro Thelma Beatriz, Juárez-Rojop Isela, Pool-García Sherezada, Genis Alma, Ble-Castillo Jorge L, Fresán Ana

Abstract excerpt

BACKGROUND: Suicidal behavior is a worldwide health problem. Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the biosynthesis of serotonergic neurotransmission. TPH-1 and TPH-2 genes encode for TPH isoforms and have been implicated as candidate genes for suicidal behavior. The aim of this study was to evaluate the association between the genetic variants of the TPH-1 (rs21102 and 1607395) and TPH-2...

Topics

Adolescent
Adult
Alleles
Case-Control Studies
Female
Genotype
Haplotypes
Humans
Male
Mexico
Middle Aged
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 26028568
DOI: 10.1016/j.comppsych.2015.05.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Suicide, Attempted

Tryptophan Hydroxylase

Young Adult