Article
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis.
Neuron - 19 Jan 2006
Dhillon Harveen, Zigman Jeffrey M, Ye Chianping, Lee Charlotte E, McGovern Robert A, Tang Vinsee, Kenny Christopher D, Christiansen Lauryn M, White Ryan D, Edelstein Elisabeth A, Coppari Roberto, Balthasar Nina, Cowley Michael A, Chua Streamson, Elmquist Joel K, Lowell Bradford B
Abstract excerpt
Leptin, an adipocyte-derived hormone, acts directly on the brain to control food intake and energy expenditure. An important question is the identity of first-order neurons initiating leptin's anti-obesity effects. A widely held view is that most, if not all, of leptin's effects are mediated by neurons located in the arcuate nucleus of the hypothalamus. However, leptin receptors (LEPRs) are expressed in other...
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