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Article

Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

12 Apr 2019

Abstract excerpt

Abstract Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of SRC-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and...

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PMID: 30979869
DOI: 10.1038/s41467-019-08737-6

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