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Article

Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity.

Endocrinology - 1 Feb 2002

Majdic Gregor, Young Morag, Gomez-Sanchez Elise, Anderson Paul, Szczepaniak Lidia S, Dobbins Robert L, McGarry J Denis, Parker Keith L

Abstract excerpt

Knockout (KO) mice lacking steroidogenic factor 1 (SF-1) exhibit a phenotype that includes adrenal and gonadal agenesis, impaired gonadotropin expression, and abnormalities of the ventromedial hypothalamic nucleus (VMH). Studies in rodents with lesions of the ventromedial hypothalamus have implicated the VMH in body weight regulation, suggesting that SF-1 KO mice may provide a genetic model of obesity. To prevent...

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Source

Identifiers

PMID: 11796516
DOI: 10.1210/endo.143.2.8652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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