Article
The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus.
Cell metabolism - 7 Oct 2014
Dodd Garron T, Worth Amy A, Nunn Nicolas, Korpal Aaron K, Bechtold David A, Allison Margaret B, Myers Martin G, Statnick Michael A, Luckman Simon M
Abstract excerpt
Leptin is a critical regulator of metabolism, which acts on brain receptors (Lepr) to reduce energy intake and increase energy expenditure. Some of the cellular pathways mediating leptin's anorectic actions are identified, but those mediating the thermogenic effects have proven more difficult to decipher. We define a population of neurons in the dorsomedial hypothalamic nucleus (DMH) containing the RFamide PrRP,...
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