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Article

LRb signals act within a distributed network of leptin-responsive neurones to mediate leptin action.

Acta physiologica (Oxford, England) - 1 Jan 2008

Leinninger G M, Myers M G

Abstract excerpt

The adipose tissue-derived hormone, leptin, acts via its receptor (LRb) in the brain to regulate energy balance and neuroendocrine function. In order to understand leptin action we have explored the physiological function of LRb signalling pathways, defining important roles for signal transducer and activator of transcription-3 (STAT3) in positive signalling and for LRbTyr(985)-mediated feedback inhibition in...

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Identifiers

PMID: 18171429
DOI: 10.1111/j.1748-1716.2007.01784.x

Genes

STAT3

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