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Article

Specific Physiological Roles for Signal Transducer and Activator of Transcription 3 in Leptin Receptor-Expressing Neurons

21 Dec 2007

Abstract excerpt

Leptin is a fat-derived hormone that exerts pleiotropic effects on energy balance and neuroendocrine functions. Mice defective in leptin or its receptor [leptin receptor, isoform b (LepRb)] exhibit profound obesity, infertility, and reduced linear growth. Leptin binding to its receptor triggers multiple signaling pathways, including signal transducer and activator of transcription 3 (Stat 3),...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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Identifiers

PMID: 18096691
DOI: 10.1210/me.2007-0389

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