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Article

[The role of leptin and its peptide mediators in neurophysiology].

Vestnik Rossiiskoi akademii meditsinskikh nauk - 1 Jan 2005

Pankov Iu A

Abstract excerpt

The adipocyte hormone leptin binds to its receptors in hypothalamic neurons and decreases appetite and food consumption. Its effect on appetite is mediated by melanocortines (MC) that are derivative of proopiomelanocortin (POMK) and their receptor (MC4-R). The knock-out of POMC gene or MC4-R gene causes obesity in animals. However, the growth of the animals intensifies and their reproductive function does not...

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Share to Adipose Tissue
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Obesity, Morbid

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Share to Receptor, Melanocortin, Type 4

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Source

Identifiers

PMID: 15776967

Genes

POMC
POMK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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