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Article

Leptin signaling and circuits in puberty and fertility

1 Aug 2012

Abstract excerpt

Leptin is an adipocyte-derived hormone involved in a myriad of physiological process, including the control of energy balance and several neuroendocrine axes. Leptin-deficient mice and humans are obese, diabetic, and display a series of neuroendocrine and autonomic abnormalities. These individuals are infertile due to a lack of appropriate pubertal development and inadequate synthesis and secretion of...

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Share to Adipose Tissue and Metabolism
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PMID: 22851226
DOI: 10.1007/s00018-012-1095-1

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