Article
Leptin mediates the increase in blood pressure associated with obesity.
Cell - 4 Dec 2014
Simonds Stephanie E, Pryor Jack T, Ravussin Eric, Greenway Frank L, Dileone Ralph, Allen Andrew M, Bassi Jaspreet, Elmquist Joel K, Keogh Julia M, Henning Elana, Myers Martin G, Licinio Julio, Brown Russell D, Enriori Pablo J, O'Rahilly Stephen, Sternson Scott M, Grove Kevin L, Spanswick David C, Farooqi I Sadaf, Cowley Michael A
Abstract excerpt
Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was not seen in animals deficient in leptin or leptin receptors (LepR). Furthermore, humans with loss-of-function mutations in leptin and the LepR have low BP despite...
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