Article
Warfarin resistance in a French strain of rats.
Journal of biochemical and molecular toxicology - 1 Jan 2005
Lasseur Romain, Longin-Sauvageon Christiane, Videmann Bernadette, Billeret Mikaëline, Berny Philippe, Benoit Etienne
Abstract excerpt
A warfarin-resistant strain and a warfarin-susceptible strain of wild rats (Rattus norvegicus) maintained in enclosures of the National Veterinary School of Lyon (France) were studied to determine the mechanism of the resistance to anticoagulant rodenticides. A low vitamin K epoxide reductase (VKOR) activity has been reported for many resistant rat strains. As recently suggested, mutations in the vitamin K...
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