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Article

Novel revelation of warfarin resistant mechanism in roof rats (Rattus rattus) using pharmacokinetic/pharmacodynamic analysis.

Pesticide biochemistry and physiology - 1 Nov 2016

Takeda Kazuki, Ikenaka Yoshinori, Tanikawa Tsutomu, Tanaka Kazuyuki D, Nakayama Shouta M M, Mizukawa Hazuki, Ishizuka Mayumi

Abstract excerpt

Roof rats (Rattus rattus) live mainly in human habitats. Heavy use of rodenticides, such as warfarin, has led to the development of drug resistance, making pest control difficult. There have been many reports regarding mutations of vitamin K epoxide reductase (VKOR), the target enzyme of warfarin, in resistant rats. However, it has been suggested there are other mechanisms of warfarin resistance. To confirm these...

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PMID: 27914534
DOI: 10.1016/j.pestbp.2016.04.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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