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Article

Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K anticoagulants.

Archives of biochemistry and biophysics - 1 Nov 2011

Hodroge Ahmed, Longin-Sauvageon Christiane, Fourel Isabelle, Benoit Etienne, Lattard Virginie

Abstract excerpt

Antivitamin K anticoagulants have been commonly used to control rodent pest all over the world for more than 50 years. These compounds target blood coagulation by inhibiting the vitamin K epoxide reductase (VKORC1), which catalyzes the reduction of vitamin K 2,3-epoxide to vitamin K. Resistance to anticoagulants has been reported in wild rat populations from different countries. From these populations, several...

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Identifiers

PMID: 21907178
DOI: 10.1016/j.abb.2011.08.010

Genes

VKORC1

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