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Article

Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of rats.

Pharmacogenetics and genomics - 1 Oct 2009

Grandemange Agnes, Kohn Michael Hans, Lasseur Romain, Longin-Sauvageon Christiane, Berny Philippe, Benoit Etienne

Abstract excerpt

OBJECTIVES: In humans, warfarin is used as an anticoagulant to reduce the risk of thromboembolic clinical events. Warfarin derivatives are also used as rodenticides in pest control. The gene encoding the protein targeted by anticoagulants is the Vitamin K-2,3-epoxide reductase subunit 1 (VKORC1). Since its discovery in 2004, various amino acid and transcription-regulatory altering VKORC1 mutations have been...

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Source

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Identifiers

PMID: 19752778
DOI: 10.1097/FPC.0b013e32832ee55b
PMCID: PMC3102556

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of rats.PMID 19752778Read ↗

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