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Article

Pesticide resistance in wild mammals--mechanisms of anticoagulant resistance in wild rodents.

The Journal of toxicological sciences - 1 Aug 2008

Ishizuka Mayumi, Tanikawa Tsutomu, Tanaka Kazuyuki D, Heewon Min, Okajima Fumie, Sakamoto Kentaro Q, Fujita Shoichi

Abstract excerpt

Warfarin is commonly used worldwide as a rodenticide. It inhibits coagulation of blood by inhibiting vitamin K 2,3-epoxide reductase (VKOR) activity. An inadequate supply of vitamin K blocks the production of prothrombin and causes hemorrhage. It has been reported that repeated or long-term treatments with this drug cause resistance in wild rodents. However, the mechanism of warfarin resistance in rodents is...

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Share to Anticoagulants
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Vitamin K Epoxide Reductases

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Source

Identifiers

PMID: 18670159
DOI: 10.2131/jts.33.283

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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