Article
Comparative genetics of warfarin resistance.
Hamostaseologie - 1 Jan 2014
Oldenburg J, Müller C R, Rost S, Watzka M, Bevans C G
Abstract excerpt
Warfarin and other 4-hydroxycoumarin-based oral anticoagulants targeting vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) are administered to humans, mice and rats with different purposes in mind - to act as pesticides in high-dosage baits for killing rodents, but also to save lives when administered in low dosages as antithrombotic drugs in humans. However, high-dosage warfarin used to control rodent...
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