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Article

A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats.

The Journal of veterinary medical science - 1 Feb 2013

Tanaka Kazuyuki D, Kawai Yusuke K, Ikenaka Yoshinori, Harunari Tsunehito, Tanikawa Tsutomu, Fujita Shoichi, Ishizuka Mayumi

Abstract excerpt

Warfarin is a rodenticide commonly used worldwide. It inhibits coagulation of blood by inhibiting vitamin K 2,3-epoxide reductase (VKOR) activity. An inadequate supply of vitamin K blocks the production of prothrombin and causes hemorrhage. Recently, warfarin-resistant brown rats (Rattus norvegicus) were found around the Aomori area of Japan. There is no significant difference in the metabolic activity of...

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Source

Identifiers

PMID: 23018795
DOI: 10.1292/jvms.12-0161

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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