Article
The VKORC1 ER-luminal loop mutation (Leu76Pro) leads to a significant resistance to warfarin in black rats (Rattus rattus).
Pesticide biochemistry and physiology - 1 Mar 2021
Takeda Kazuki, Ikenaka Yoshinori, Fourches Denis, Tanaka Kazuyuki D, Nakayama Shouta M M, Triki Dhoha, Li Xinhao, Igarashi Manabu, Tanikawa Tsutomu, Ishizuka Mayumi
Abstract excerpt
Well-known 4-hydroxycoumarin derivatives, such as warfarin, act as inhibitors of the vitamin K epoxide reductase (VKOR) and are used as anticoagulants. Mutations of the VKOR enzyme can lead to resistance to those compounds. This has been a problem in using them as medicine or rodenticide. Most of these mutations lie in the vicinity of potential warfarin-binding sites within the ER-luminal loop structure (Lys30,...
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