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Article

New approaches to combating antimicrobial drug resistance.

Genome biology - 1 Jan 2005

Avison Matthew B

Abstract excerpt

Recent work shows that the inhibition of the SOS stress response in Escherichia coli reduces the development of resistance to the antibiotics ciprofloxacin and rifampicin. This finding may help in the battle against the rise of resistance to antimicrobial drugs.

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Topics

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Share to Anti-Bacterial Agents
Share to Drug Resistance, Bacterial
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Biological

Share to Mutation

Share to SOS Response, Genetics

Source

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Identifiers

PMID: 16420675
DOI: 10.1186/gb-2005-6-13-243
PMCID: PMC1414098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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New approaches to combating antimicrobial drug resistance.PMID 16420675Read ↗

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Synergistic Effect of SOS Response and GATC Methylome Suppression on Antibiotic Stress Survival in Escherichia coli.Semantic proximity Read ↗

Complete and SOS-mediated response of Staphylococcus aureus to the antibiotic ciprofloxacin.Semantic proximity Read ↗

Chemical proteomics identifies signal peptidase IB (SpsB) as a target of the SOS response inhibitor OXF-077 and a regulator of quinolone resistance emergence in <i>Staphylococcus aureus</i>Semantic proximity Read ↗

Drugging evolution of antibiotic resistance at a regulatory network hub.Semantic proximity Read ↗

Effects of Stress, Reactive Oxygen Species, and the SOS Response on De Novo Acquisition of Antibiotic Resistance in Escherichia coli.Semantic proximity Read ↗

Role of the SOS Response in the Generation of Antibiotic Resistance In Vivo.Semantic proximity Read ↗

Antimicrobials as promoters of genetic variation.Semantic proximity Read ↗

Inhibition of mutation and combating the evolution of antibiotic resistance.Semantic proximity Read ↗

Fluoroquinolone-Specific Resistance Trajectories in E. coli and their Dependence on the SOS-ResponseSemantic proximity Read ↗

Quinolone-resistant gyrase mutants demonstrate decreased susceptibility to triclosan.Semantic proximity Read ↗

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