Back to search

Article

Chemical proteomics identifies signal peptidase IB (SpsB) as a target of the SOS response inhibitor OXF-077 and a regulator of quinolone resistance emergence in <i>Staphylococcus aureus</i>

2025-11-23

Abstract excerpt

Antimicrobial resistance (AMR) is an existential threat to health globally, and novel compounds that act through new targets are urgently required to combat increasing levels of resistance. One emerging strategy is the development of ‘antibiotic adjuvants’ that can slow the evolution of resistance by inhibiting the mutagenic SOS response in bacteria, in order to prolong the clinical lifetime of antibiotics. OXF-0...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0e8af9f5-c362-5bd8-8dcb-0539cef91626
DOI
10.1101/2025.11.21.689737
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Chemical proteomics identifies signal peptidase IB (SpsB) as a target of the SOS response inhibitor OXF-077 and a regulator of quinolone resistance emergence in <i>Staphylococcus aureus</i>DOI 10.1101/2025.11.21.689737
Staphylococcus aureus SOS response: Activation, impact, and drug targetsSemantic proximity
Chemoproteomics of an Indole-Based Quinone Epoxide Identifies Druggable Vulnerabilities in Vancomycin-Resistant Staphylococcus aureusSemantic proximity
Snapshots of <i>Pseudomonas aeruginosa</i> SOS response activation complex reveal structural prerequisites for LexA engagement and cleavageSemantic proximity
Identification and structural characterization of novel bacteriocins by genome-wide screening of hypothetical mini-proteins in Staphylococcus aureusSemantic proximity
Bacteriocin Distribution Patterns in <i>Enterococcus faecium</i> and <i>Enterococcus lactis:</i> Bioinformatic Analysis Using a Tailored Genomics FrameworkSemantic proximity
Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteriaSemantic proximity
Phenotypic and multi-omics characterization of <i>Escherichia coli</i> K-12 adapted to quaternary ammonium compounds identifies lipid A and cell envelope alterations regulated by mar-sox-rob and stress inducible pathwaysSemantic proximity
Genome-wide screening and characterization of genes involved in response to high dose of ciprofloxacin in Escherichia coliSemantic proximity
TetR and OmpR family regulators in natural product biosynthesis and resistanceSemantic proximity
Boronic acid derivative inhibits LexA mediated SOS response in MycobacteriaSemantic proximity
High-level carbapenem tolerance requires antibiotic-induced outer membrane modificationsSemantic proximity
Differential expression of outer membrane proteins and quinolone resistance determining region mutations can lead to ciprofloxacin resistance in Salmonella Typhi.Semantic proximity
Select a neighboring publication to make it the new centre.