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Article

Synergistic Effect of SOS Response and GATC Methylome Suppression on Antibiotic Stress Survival in Escherichia coli.

Antimicrobial agents and chemotherapy - 16 Mar 2023

Diaz-Diaz S, Recacha E, Pulido Marina R, Romero-Muñoz María, de Gregorio-Iaria B, Docobo-Pérez F, Pascual A, Rodríguez-Martínez J M

Abstract excerpt

The suppression of the SOS response has been shown to enhance the in vitro activity of quinolones. Furthermore, Dam-dependent base methylation has an impact on susceptibility to other antimicrobials affecting DNA synthesis. Here, we investigated the interplay between these two processes, alone and in combination, in terms of antimicrobial activity. A genetic strategy was used employing single- and double-gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36802234
DOI: 10.1128/aac.01392-22
PMCID: PMC10019295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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