Article
Antimicrobials as promoters of genetic variation.
Current opinion in microbiology - 1 Oct 2012
Blázquez Jesús, Couce Alejandro, Rodríguez-Beltrán Jerónimo, Rodríguez-Rojas Alexandro
Abstract excerpt
The main causes of antibiotic resistance are the selection of naturally occurring resistant variants and horizontal gene transfer processes. In recent years, the implications of antibiotic contact or treatment in drug resistance acquisition by bacteria have been gradually more evident. The ultimate source of bacterial genetic alterations to face antibiotic toxicity is mutation. All evidence points to antibiotics,...
Read the complete abstract on PubMedTopics
- Anti-Bacterial Agents
- Bacteria
- DNA Damage
- Gene Transfer, Horizontal
- Genetic Variation
- Mutation
- Oxidative Stress