Article
Inhibition of mutation and combating the evolution of antibiotic resistance.
PLoS biology - 1 Jun 2005
Cirz Ryan T, Chin Jodie K, Andes David R, de Crécy-Lagard Valérie, Craig William A, Romesberg Floyd E
Abstract excerpt
The emergence of drug-resistant bacteria poses a serious threat to human health. In the case of several antibiotics, including those of the quinolone and rifamycin classes, bacteria rapidly acquire resistance through mutation of chromosomal genes during therapy. In this work, we show that preventing induction of the SOS response by interfering with the activity of the protease LexA renders pathogenic Escherichia...
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