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Article

Quinolone Resistance Reversion by Targeting the SOS Response.

mBio - 10 Oct 2017

Recacha E, Machuca J, Díaz de Alba P, Ramos-Güelfo M, Docobo-Pérez F, Rodriguez-Beltrán J, Blázquez J, Pascual A, Rodríguez-Martínez J M

Abstract excerpt

Suppression of the SOS response has been postulated as a therapeutic strategy for potentiating antimicrobial agents. We aimed to evaluate the impact of its suppression on reversing resistance using a model of isogenic strains of Escherichia coli representing multiple levels of quinolone resistance. E. coli mutants exhibiting a spectrum of SOS activity were constructed from isogenic strains carrying quinolone...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29018116
DOI: 10.1128/mBio.00971-17
PMCID: PMC5635686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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