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Article

Ciprofloxacin-Mediated Mutagenesis Is Suppressed by Subinhibitory Concentrations of Amikacin in Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Mar 2017

Valencia Estela Ynés, Esposito Fernanda, Spira Beny, Blázquez Jesús, Galhardo Rodrigo S

Abstract excerpt

Resistance to antibiotics is a global health problem. Activation of the SOS response, and the subsequent elevation in mutagenesis, contributes to the appearance of resistance mutations. Among currently used drugs, quinolones are the most potent inducers of the SOS response. In the present study, we show that amikacin inhibits ciprofloxacin-mediated SOS induction and mutagenesis in Pseudomonas aeruginosa.

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Identifiers

PMID: 28031197
DOI: 10.1128/AAC.02107-16
PMCID: PMC5328548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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