Article
A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.
Cancer discovery - 1 Aug 2015
Hoffmann Thomas J, Van Den Eeden Stephen K, Sakoda Lori C, Jorgenson Eric, Habel Laurel A, Graff Rebecca E, Passarelli Michael N, Cario Clinton L, Emami Nima C, Chao Chun R, Ghai Nirupa R, Shan Jun, Ranatunga Dilrini K, Quesenberry Charles P, Aaronson David, Presti Joseph, Wang Zhaoming, Berndt Sonja I, Chanock Stephen J, McDonnell Shannon K, French Amy J, Schaid Daniel J, Thibodeau Stephen N, Li Qiyuan, Freedman Matthew L, Penney Kathryn L, Mucci Lorelei A, Haiman Christopher A, Henderson Brian E, Seminara Daniela, Kvale Mark N, Kwok Pui-Yan, Schaefer Catherine, Risch Neil, Witte John S
Abstract excerpt
UNLABELLED: A genome-wide association study (GWAS) of prostate cancer in Kaiser Permanente health plan members (7,783 cases, 38,595 controls; 80.3% non-Hispanic white, 4.9% African-American, 7.0% East Asian, and 7.8% Latino) revealed a new independent risk indel rs4646284 at the previously identified locus 6q25.3 that replicated in PEGASUS (N = 7,539) and the Multiethnic Cohort (N = 4,679) with an overall P = 1.0...
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