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Article

Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2.

Current drug metabolism - 1 Jul 2008

Walraven Jason M, Zang Yu, Trent John O, Hein David W

Abstract excerpt

Arylamine N-acetyltransferase 2 (NAT2) modifies drug efficacy/toxicity and cancer risk due to its role in bioactivation and detoxification of arylamine and hydrazine drugs and carcinogens. Human NAT2 alleles possess a combination of single nucleotide polymorphisms (SNPs) associated with slow acetylation phenotypes. Clinical and molecular epidemiology studies investigating associations of NAT2 genotype with drug...

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Source

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Identifiers

PMID: 18680467
DOI: 10.2174/138920008784892065
PMCID: PMC2507886

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2.PMID 18680467Read ↗

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Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.Semantic proximity Read ↗

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