Article
Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands.
Gut - 1 Dec 2002
van Rijnsoever M, Grieu F, Elsaleh H, Joseph D, Iacopetta B
Abstract excerpt
BACKGROUND AND AIMS: A subgroup of colorectal cancers (CRC) referred to as the CpG island methylator phenotype (CIMP+) shows simultaneous methylation of multiple CpG islands. The clinicopathological and molecular characteristics of this phenotype remain uncertain however. METHODS: We analysed methylation of CpG islands in the p16 and MDR1 genes and MINT-2 clone in 275 stage II/III CRCs. RESULTS: Concurrent...
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