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Article

Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context.

Human molecular genetics - 15 Feb 2006

Chen Hongmin, Wilkins Leon M, Aziz Nazneen, Cannings Christopher, Wyllie David H, Bingle Colin, Rogus John, Beck James D, Offenbacher Steven, Cork Michael J, Rafie-Kolpin Maryam, Hsieh Chung-Ming, Kornman Kenneth S, Duff Gordon W

Abstract excerpt

We questioned the significance of haplotype structure in gene regulation by testing whether individual single nucleotide polymorphisms (SNPs) within a gene promoter region [interleukin-1-beta (IL1B)] might affect promoter function and, if so, whether function was dependent on haplotype context. We sequenced genomic DNA from 25 individuals of diverse ethnicity, focusing on exons and upstream flanking regions of...

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PMID: 16399797
DOI: 10.1093/hmg/ddi469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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