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Article

Interleukin-6 promoter haplotypes and interleukin-6 cytokine responses.

Shock (Augusta, Ga.) - 1 Sept 2003

Rivera-Chavez Fernando A, Peters-Hybki Dixie L, Barber Robert C, O'Keefe Grant E

Abstract excerpt

Genetic variations contribute to differences in the inflammatory response and are markers for disease risk and outcomes. We studied three single-nucleotide polymorphisms (-597 G-->A, -572 G-->C, and -174 G-->C) in the IL-6 promoter to determine associations with ex vivo LPS-stimulated IL-6 production by leukocytes. We also measured nuclear protein binding to synthetic oligonucleotides representing the -174...

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PMID: 12923492
PMCID: PMC1383770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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