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Article

Differential effect of ABCB1 haplotypes on promoter activity.

Pharmacogenetics and genomics - 1 Mar 2018

Speidel Jordan T, Xu Meixiang, Abdel-Rahman Sherif Z

Abstract excerpt

OBJECTIVE: Promoter single-nucleotide polymorphisms (SNPs) of the ABCB1 gene, encoding the placental efflux transporter P-glycoprotein, can affect its expression and alter xenobiotic transfer from the maternal to the fetal circulation. Because SNPs are arranged in specific combinations as defined haplotypes, the aims of this study were to: (i) determine the placental haplotype structure of the ABCB1 promoter and...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Share to Fetal Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29232306
DOI: 10.1097/FPC.0000000000000323
PMCID: PMC5792297

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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