Article
Haplotypes in the expression quantitative trait locus of interleukin-1β gene are associated with schizophrenia.
Schizophrenia research - 1 Sept 2012
Yoshida Masakuni, Shiroiwa Kyoichi, Mouri Kentaro, Ishiguro Hiroki, Supriyanto Irwan, Ratta-Apha Woraphat, Eguchi Noriomi, Okazaki Satoshi, Sasada Toru, Fukutake Masaaki, Hashimoto Takeshi, Inada Toshiya, Arinami Tadao, Shirakawa Osamu, Hishimoto Akitoyo
Abstract excerpt
Recent genome-wide association study (GWAS) and gene expression analyses have revealed that single nucleotide polymorphisms (SNPs) associated with complex diseases such as schizophrenia are significantly more likely to be associated with expression quantitative trait loci (eQTL). The interleukin-1β (IL1B) gene has been strongly implicated in the susceptibility to schizophrenia. In order to test this association,...
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