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IL1B gene promoter haplotype pairs predict clinical levels of interleukin-1beta and C-reactive protein.

Human genetics - 1 May 2008

Rogus John, Beck James D, Offenbacher Steven, Huttner Kenneth, Iacoviello Licia, Latella Maria Carmela, de Gaetano Monica, Wang Hwa-Ying, Kornman Kenneth S, Duff Gordon W

Abstract excerpt

Interleukin-1beta (IL-1beta) activates inflammatory mediator cascades and has been implicated in the pathogenesis of several diseases. Single nucleotide polymorphisms (SNPs) of the IL1B promoter have been associated with various inflammatory diseases. We recently reported that IL1B gene transcription was influenced by four promoter SNPs, and that individual SNP function in vitro was governed by haplotype context....

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PMID: 18369665
DOI: 10.1007/s00439-008-0488-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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