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Article

Functional impact of sequence variation in the promoter region of TGFB1.

International journal of cancer - 15 Sept 2009

Healy Jasmine, Dionne Joëlle, Bélanger Hélène, Larivière Mathieu, Beaulieu Patrick, Labuda Damian, Sinnett Daniel

Abstract excerpt

Pathological deregulation of the transforming growth factor, beta 1 (TGFB1) pathway has been implicated in the development of several major diseases, including cancers. Regulatory variation in the TGFB1 gene may lead to altered TGFB1 expression and activity, and thus, modulate an individual's susceptibility to disease. Here, we performed a study of the functional relevance of cis-acting regulatory variation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19536820
DOI: 10.1002/ijc.24526

Genes

TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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