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Article

Polymorphisms in the 5'-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expression.

Molecular psychiatry - 1 Nov 2003

Duan J, Sanders A R, Molen J E Vander, Martinolich L, Mowry B J, Levinson D F, Crowe R R, Silverman J M, Gejman P V

Abstract excerpt

We present evidence of complex balancing regulation of HTR1B transcription by common polymorphisms in its promoter. Computational analysis of the HTR1B gene predicted that a 5' segment, spanning common DNA sequence variations, T-261G, A-161T, and -182INS/DEL-181, contained a putative functional promoter. Using a secreted alkaline phosphatase (SEAP) reporter gene system, we found that the haplotype...

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PMID: 14593427
DOI: 10.1038/sj.mp.4001403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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