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Article

Functional characterisation of bovine interleukin 8 promoter haplotypes in vitro.

Molecular immunology - 1 Feb 2012

Meade Kieran G, O'Gorman Grace M, Narciandi Fernando, Machugh David E, O'Farrelly Cliona

Abstract excerpt

Interleukin 8 (IL-8) is a major mediator of the innate immune response and polymorphisms in this gene are associated with susceptibility to inflammatory disease in humans. The aim of this study was to characterise the promoter region of the bovine IL8 gene towards understanding its regulation and the effect of promoter polymorphisms on gene expression levels. Twenty-nine polymorphic sites were identified across a...

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PMID: 22244152
DOI: 10.1016/j.molimm.2011.12.011

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TNF

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