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Article

Haplotype-oriented genetic analysis and functional assessment of promoter variants in the MDR1 (ABCB1) gene.

The Journal of pharmacology and experimental therapeutics - 1 Dec 2004

Takane Hiroshi, Kobayashi Daisuke, Hirota Takeshi, Kigawa Junzo, Terakawa Naoki, Otsubo Kenji, Ieiri Ichiro

Abstract excerpt

Recently, a number of nucleotide variants have been described in the multidrug resistance 1 (MDR1/ABCB1) gene; however, most studies have focused on the coding region. In the present study, we identified promoter variants of the MDR1 gene and evaluated their phenotypic consequences using a report...

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Identifiers

PMID: 15280437
DOI: 10.1124/jpet.104.069724

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15280437-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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