Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haplotype structure of inflammatory cytokines genes (IL1B, IL6 and TNF/LTA) in US Caucasians and African Americans.

Genes and immunity - 1 Sept 2004

Belfer I, Buzas B, Hipp H, Dean M, Evans C, Lorincz I, Max M B, Goldman D

Abstract excerpt

The major inflammatory cytokines interleukin(IL)1beta, IL6 and tumor necrosis factor alpha (TNFalpha) play a crucial role in infection, inflammation and stress responses. Previously, three coding genes were resequenced, identifying promoter polymorphisms that were used in association studies of neurodegenerative diseases, metabolic disorders and cancer. These studies have produced intriguing but inconsistent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammation

Share to Interleukin-1

Share to Interleukin-6

Share to Lymphotoxin-alpha

Share to United States

Share to White People

Source

Identifiers

PMID: 15306845
DOI: 10.1038/sj.gene.6364118

Genes

TNF
LTA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haplotype structure of inflammatory cytokines genes (IL1B, IL6 and TNF/LTA) in US Caucasians and African Americans.PMID 15306845Read ↗

Genetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer.Semantic proximity Read ↗

A novel single nucleotide polymorphism and five probable haplotypes in the 5' flanking region of the IL-6 gene in African-Americans.Semantic proximity Read ↗

Novel IL-6 haplotypes and disease association.Semantic proximity Read ↗

TNF-alpha promoter single nucleotide polymorphisms are markers of human ancestry.Semantic proximity Read ↗

Differential distribution of allelic variants in cytokine genes among African Americans and White Americans.Semantic proximity Read ↗

IL1B gene promoter haplotype pairs predict clinical levels of interleukin-1beta and C-reactive protein.Semantic proximity Read ↗

Genome-wide association study of circulating interleukin 6 levels identifies novel loci.Semantic proximity Read ↗

Interleukin-6 promoter haplotypes and interleukin-6 cytokine responses.Semantic proximity Read ↗

Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses.Semantic proximity Read ↗

Structure of tumor necrosis factor-alpha haploblocks in European populations.Semantic proximity Read ↗

Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers.Semantic proximity Read ↗

Interleukin-1B (IL1B) and interleukin-6 (IL6) gene polymorphisms are associated with risk of chronic lymphocytic leukaemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.