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Cooperative Influence of Genetic Polymorphisms on Interleukin 6 Transcriptional Regulation

1 Jun 2000

Abstract excerpt

Interleukin 6 (IL6) plays key roles in hematopoiesis, immune, and acute phase responses. Dysregulated IL6 expression is implicated in diseases such as atherosclerosis and arthritis. We have examined the functional effect of four polymorphisms in the IL6 promoter (-597G-->A, -572G-->C, -373A(n)T(n), -174G-->C) by identifying the naturally occurring haplotypes and comparing their effects on reporter gene...

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PMID: 10747905
DOI: 10.1074/jbc.m000379200

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