Article
Linkage disequilibrium and haplotype blocks in the MHC vary in an HLA haplotype specific manner assessed mainly by DRB1*03 and DRB1*04 haplotypes.
Genes and immunity - 1 Mar 2006
Blomhoff A, Olsson M, Johansson S, Akselsen H E, Pociot F, Nerup J, Kockum I, Cambon-Thomsen A, Thorsby E, Undlien D E, Lie B A
Abstract excerpt
First generation linkage disequilibrium (LD) and haplotype maps of the human major histocompatibility complex (MHC) have been generated in order to aid the unraveling of the numerous disease predisposing genes in this region by offering a first set of haplotype tagSNPs. Several parameters, like the population studied, the marker map used, the density of polymorphisms and the applied algorithm, are influencing the...
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