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Article

Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2011

Ittiwut Rungnapa, Listman Jennifer B, Ittiwut Chupong, Cubells Joseph F, Weiss Roger D, Brady Kathleen, Oslin David, Farrer Lindsay A, Kranzler Henry R, Gelernter Joel

Abstract excerpt

Catechol-O-methyltransferase (genetic locus, COMT) is a major enzyme involved in catecholamine metabolism and has been associated with numerous psychiatric phenotypes. We studied COMT SNPs and haplotypes in cocaine-induced paranoia (CIP) in African-American (AA) and European-American (EA) populations. We genotyped 17 SNPs across the COMT locus in 319 AA pedigrees (848 individuals) and 302 EA pedigrees (707...

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Identifiers

PMID: 21656904
DOI: 10.1002/ajmg.b.31205
PMCID: PMC3864552

Genes

COMT

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Source receipt: pubmed, retrieved 7 Sept 2026.

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