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Article

The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.

Molecular psychiatry - 1 Feb 2010

Mukherjee N, Kidd K K, Pakstis A J, Speed W C, Li H, Tarnok Z, Barta C, Kajuna S L B, Kidd J R

Abstract excerpt

Genetic variation at the catechol-O-methyltransferase (COMT) gene has been significantly associated with risk for various neuropsychiatric conditions such as schizophrenia, panic disorder, bipolar disorders, anorexia nervosa and others. It has also been associated with nicotine dependence, sensitivity to pain and cognitive dysfunctions especially in schizophrenia. The non-synonymous single nucleotide polymorphism...

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Share to Catechol O-Methyltransferase
Share to Databases, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Predisposition to Disease

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 18574484
DOI: 10.1038/mp.2008.64
PMCID: PMC2811226

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.PMID 18574484Read ↗

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The catechol-O-methyltransferase gene: its regulation and polymorphisms.Semantic proximity Read ↗

Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations.Semantic proximity Read ↗

Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.Semantic proximity Read ↗

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Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.Semantic proximity Read ↗

Association study of candidate variants of COMT with neuroticism, anxiety and depression.Semantic proximity Read ↗

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