Article
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility.
Proceedings of the National Academy of Sciences of the United States of America - 13 May 2003
Smirnova Irina, Mann Navjiwan, Dols Annemiek, Derkx H H, Hibberd Martin L, Levin Michael, Beutler Bruce
Abstract excerpt
As the central component of the human endotoxin sensor, Toll-like receptor 4 (TLR4) functions in the early detection and response to Gram-negative infection. We therefore examined a large collection of patients with meningococcal sepsis, comparing the frequency of rare TLR4 coding changes to those in an ethnically matched control population. TLR2 sequences were also acquired and compared. Total nucleotide...
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