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Article

Loss of Werner syndrome protein function promotes aberrant mitotic recombination.

Genes & development - 15 Apr 2001

Prince P R, Emond M J, Monnat R J

Abstract excerpt

The chromosome 8p11-12 Werner syndrome (WRN ) locus encodes a RecQ helicase protein of unknown function that possesses both 3' --> 5' helicase and 3' --> 5' exonuclease activities. We show that WRN cell lines display a marked reduction in cell proliferation following mitotic recombination, and ge...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11316787
DOI: 10.1101/gad.877001
PMCID: PMC312674

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11316787-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Loss of Werner syndrome protein function promotes aberrant mitotic recombination.PMID 11316787Read ↗

Depletion of Werner helicase results in mitotic hyperrecombination and pleiotropic homologous and nonhomologous recombination phenotypes.Semantic proximity Read ↗

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Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

Werner Protein Protects Nonproliferating Cells from Oxidative DNA DamageSemantic proximity Read ↗

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrestSemantic proximity Read ↗

Telomere dysfunction as a cause of genomic instability in Werner syndromeSemantic proximity Read ↗

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Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.Semantic proximity Read ↗

Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cellsSemantic proximity Read ↗

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